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This enhancement is demonstrable through an increase in mitochondrial DNA content, the upregulation of genes integral to mitochondrial biogenesis, and the increased expression of proteins pivotal in oxidative phosphorylation

Long-term use of glutathione has occasionally been associated with lower zinc levels, so it is a good idea to have your levels checked periodically by your family doctor if you plan on long-term supplementation

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It also raises stress hormones, which lowers glutathione action in a roundabout way