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Wang B, Yang LP, Zhang XZ, Huang SQ, Bartlam M, Zhou SF (2009) New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme

Accordingly, GGTs from eukaryotes and Gram-negative organisms have been termed as lid-loop positive and GGTs from Bacillus species, archaea, and extremophiles as lid-loop negative