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Even if the exact conversion mechanism has not been characterised yet, a limited conversion capacity in Western populations (about 25 %) has been highlighted, as opposed to the greater competence of Asian populations (50 %), estimated through urinary equol excretion (Reference Setchell, Brown and Lydeking-Olsen17)

Thus, glutamatergic dysfunction in schizophrenia is certainly associated to metabolic impairments

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As stated earlier, NAPQI is a reactive electrophile which is an alkylating agent of the thiol groups (Rocha et al ., 2005

Nat Rev Microbiol 21 , 555572 (2023)