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Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration

In the long term, increasing the level of prooxidant factors can cause structural defects in mitochondrial DNA and alterations in enzymatic functionality or cellular structures, with the appearance of functional, structural abnormalities or aberrations in gene expression

In our experiments, the obtained pro-oxidative activity of GSH can support the hypothesized Janus-faced character of the redox axis

Diagnosis is made by measuring the concentration of different metabolites in the -glutamyl cycle and homocysteine, enzyme activity, and/or mutation analysis

Schmoll D, Engel CK, Glombik H