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Furthermore, KEGG pathway enrichment analysis demonstrated significant enrichment of purine metabolism, valine, leucine, and isoleucine biosynthesis, arginine biosynthesis, the pentose phosphate pathway (PPP), and histidine metabolism in LPS-induced pneumonia, while papain-induced pneumonia primarily enriched the one-carbon pool by folate, alanine aspartate, and glutamate metabolism, glycine, serine, and threonine metabolism, cysteine and methionine metabolism, and the PPP (Figures 2C, E)

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