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First, although SLC30A10 mediates the release of Mn from the brain and SLC39A8 facilitates its uptake 312 , the precise mechanisms that regulate neuronal Mn transport and accumulation remain poorly understood

FIGURE 8 4 Conclusion In summary, a novel RBC-coated biomimetic self-cascade bioreactor (RBC@SeMSN@Uri) was designed and synthesized for the treatment of hyperuricemia and gout

In glaucoma, the increased levels of A, p-tau, and amyloid precursor protein initiate an inflammatory response, leading to cytokine secretion and iron overload

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Sheaffer KL

This led to GSH depletion, a burst of lipid peroxides, and accumulation of labile iron, collectively triggering ferroptosis