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These IR-induced mitochondrial defects are evident in both insulin-sensitive tissues (liver, muscle) and in the heart and brain, providing a mechanistic link between metabolic dysfunction and cardiovascularcognitive comorbidity

Breyanzi won approval in these new indications based on results from the pivotal TRANSCENT CLL 004 trial, where treatment with the CAR-T therapy elicited a complete response rate of 20% and an overall response rate of 45%, with responses lasting more than 35 months

BPC-157 is often most used to treat stomach and intestinal conditions such as inflamed intestinal epithelium (leaky gut), eosinophilic esophagitis, and inflammatory bowel disease

E2 decline also promotes mitochondrial fission, resulting in fragmented mitochondria with disorganized cristae and reduced inter-organelle connectivity

Lamming joins me on this episode to [] Listen