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The interplay between T cells and dendritic cells is promoted by pdpn-expressing fibroblastic reticular cells in conjunction with pdpn + stromal fibroblasts, facilitating the transition from innate to adaptive immunity within TLS (38, 142, 143)

Metabolite treatment increased the endogenous levels of individual treated metabolites in each treatment group compared to the control group (Supplementary Fig

3.3.1 Antioxidant activity Substances such as shikonin, alkanin, lawsone, emodin, epigallocatechin-3-gallate, and ellagic acid, along with certain herbal extracts, act as potent antioxidants by scavenging reactive oxygen species (ROS), inhibiting lipid peroxidation, and enhancing the activities of intracellular antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px)

When respiratory inflammation occurs, these mucins form thick, viscous plugs that are incredibly difficult to clear, leading to chronic congestion and shortness of breath

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