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According to the World Health Organization and the International Committee for Monitoring Assisted Reproductive Technology, infertility is a reproductive system disease defined as the failure to achieve clinical pregnancy after 12 months or more of routine unprotected sex ( via semen analysis, including determination of the sperm concentration/total number, motility, and morphology ( Genetic abnormalities can lead to spermatogenic disorders and account for 1530% of male infertility ( Chemical elements play important roles in male reproduction because imbalance of micronutrients or macronutrients may lead to spermatogenesis defects and decreased libido, resulting in male infertility

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The same team also evaluated the potential of toluidine blue (TB), another photosensitizer on MSN encapsulation and activity against biofilms formed by P