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Trial data does not support claims of steroid-scale transformations from secretagogue stacks alone

N Engl J Med 365(4):327336

GDF15 regulates the metabolic pathways of macrophages, acquiring an anti-inflammatory function dependent on oxidative phosphorylation, reducing the expression of pro-inflammatory factors, and decreasing the infiltration of monocytes and neutrophils into the liver, thereby alleviating liver inflammation [174, 175]