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Moreover, the more hydrophobic substrates tyramine and dopamine could be further stabilized by the hydrophobic 2 nd activity controller Leu244, which is supported by the experimental results ( K m values: tyramine = 0.451, dopamine = 0.75 versus tyrosine = 1.42 and L -DOPA = 6.2)

(Shanghai, China) and the sequences are listed in Supplementary Table 3

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24,25 Nonetheless, there is evidence that NAFLD is associated with a higher risk of CKD, even after ruling out contributing factors such as obesity and diabetes

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