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ODD is a research incentiveit provides benefits including extended market exclusivity upon approval, tax credits for clinical trial costs, and expedited reviewnot an evaluation of the compounds safety or efficacy

3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)

doi: 10.3324/haematol.2020.246603

doi: 10.3389/fnins.2025.1602149 Received 28 March 2025 Accepted 21 May 2025 Published 04 June 2025 Volume 19 - 2025 Edited by Xiao-Yuan Mao, Central South University, China Reviewed by Cai Qi, Yale University, United States Fiorella Colasuonno, University of Rome Tor Vergata, Italy Updates Copyright 2025 Valenzuela-Ahumada, Mercado-Gmez, Viveros-Contreras, Guevara-Guzmn and Camacho-Morales

Wensing KU, Ciarimboli G