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Infusion of adenosine directly into the knee in rats inhibited the development of adjuvant-induced arthritis, and an adenosine receptor antagonist effectively reduced the severity of joint inflammation in a collagen-induced arthritis model in mice [39, 40]

M., Perry, G

To address the ROS burst driven by ferroptosis and the imbalance of iron homeostasis, a study has developed a macrophage-targeting polysaccharide iron nanoenzyme, which possesses dual enzyme activities resembling catalase and peroxidase, capable of scavenging ROS, inhibiting lipid peroxidation, and controllably releasing Fe 2 to correct systemic iron deficiency [150]

Similarly, in ultrasound-triggered ROS generation systems such as lenvatinib nanoparticles (Len-RNPs), precise tumor targeting is essential to ensure that ROS are generated exclusively at the tumor site, thereby minimizing damage to surrounding healthy tissues