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Classical antifolate drugs, including methotrexate (targeting DHFR) [153] and fluoropyrimidine agents (targeting TYMS) [154], induce cell death in rapidly proliferating malignancies by specifically inhibiting key enzymes in 1 C metabolism, thereby depleting nucleotide pools and causing replication stress [101]

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Fasano A

The IV bag hangs on a pole next to you, and gravity helps the fluid flow into your vein

To further assess the reduced survival associated with CINPA1, liver and blood samples were collected 24h after sham or CLP surgery ( Figure 6C )

Signaling by target of rapamycin proteins in cell growth control