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Description

Despite these benefits, some PPAR agonists, such as rosiglitazone and pioglitazone, have been associated with increased heart failure due to direct or indirect cardiac effects, such as fluid retention (3)

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Binding to a receptor may open ion channels, trigger second messengers like cyclic AMP, or turn on kinase cascades that regulate gene expression

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Some cited clinical trials are small

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It has since been studied extensively for its role in supporting sleep quality and the body's natural sleep architecture

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The RGD tripeptide anticancer drug carrier: DFT computations and molecular dynamics simulations

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