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FRDA is a rare disease, hence the challenge of recruiting large number of patients to impact clinical significance is one which cannot be underestimated

In the traditional view, oxidative stress was thought to result from a global disruption in the pro-oxidant and antioxidant balance (296)

GLP-1 receptor agonists Liraglutide: Liraglutide has shown anti-inflammatory properties

Specifically, in male patients with GBA1 mutations, robust volcano-plot analysis revealed decreased levels of L-glutamic acid, L-alanine, choline, malonate, acetic acid, and pyruvic acid, coupled with upregulation of L-methionine and 3-hydroxybutyric acid compared with control subjects

10.3390/molecules25020368 Nzila A (2018) Current status of the degradation of aliphatic and aromatic petroleum hydrocarbons by thermophilic microbes and future perspectives