Exosomes can play a vital role in intra- and inter-cellular communication via selective packaging and transport of microRNAs (miRNAs), mRNAs, proteins, and other biological cargos to neighboring cells or to distant tissues via biofluids such as plasma, urine, cerebrospinal fluid, etc
Experimental approach (biological evaluation) In vitro enzyme bioassay The inhibitory activity of selected hits against GLO-I was assessed in vitro using recombinant human GLO-I (rhGLO-I) 34,35
Glutathione plays a crucial role in protecting cells from oxidative stress, which is implicated in the pathogenesis of many diseases, including neurodegenerative disorders, cardiovascular diseases, and liver diseases
As GO enrichment scatterplot shown in Figure 3B, the most DEGs were distributed in the cytosolic large ribosomal subunit, cellular component, structural constituent of ribosome, obsolete oxidationreduction process, mitochondrion, biological process, translation, cytosolic small ribosomal subunit, oxidoreductase activity, molecular function, plasma membrane, extracellular region, nucleus, and zinc ion binding terms based on the gene number and enrichment factors
Protein malnutrition can also alter drug metabolism causing undesirable responses to medication
