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For athletes specifically, how to reduce cramps when running comes down to race-pace hydration, pre-race sodium loading, consistent training (not sudden volume spikes), and post-run stretching of the calves, hamstrings, and hip flexors

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Key differences in bioavailability: Prescription injections: High bioavailability due to direct delivery into the bloodstream OTC oral supplements: Variable bioavailability due to gastrointestinal absorption factors Understanding the differences between prescription B12 injections and OTC supplements helps healthcare providers tailor treatments