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Regarding the triple combination, the pathways are highly similar to those of (M+D)/2, with an additional enrichment in pathways associated with anion transmembrane transporter activity ( Figure 7B )

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Emphasize: Cruciferous vegetables (broccoli, kale, Brussels sprouts): rich in sulforaphane, a potent NRF2 activator Clean protein (wild-caught fish, grass-fed beef, organic poultry): to support glutathione synthesis and liver repair Colorful plant foods (berries, leafy greens, beets): loaded with polyphenols and antioxidants Sulfur-rich foods (garlic, onions, eggs): to enhance Phase II detox pathways Avoid processed foods, inflammatory oils, and excess sugar, which burden detox pathways and fuel oxidative stress

CR, another way to create hormetic stress, induces remodeling of the ETC architecture and cristae morphology

LRE mechanistically elevated antioxidant enzymes such as GPX-4, Prdx-5, HO-1, and SOD-2, which are essential for alleviating oxidative damage