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The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris

Dssing M, Arlien-Sborg P, Petersen L, Ranek L

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The researchers observed increased frequencies of anti-inflammatory macrophages and higher IL-6 and IL-8 concentrations in the milk of mothers whose infants had an ongoing respiratory infection, indicating that the composition of breast milk changes according to the infants needs to ensure neonatal protection (252)