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Like NCC KO islets, those from mice lacking NCC exclusively in -cells (NCC KO ) showed preserved glucose-stimulated insulin secretion

Ranaivo H, Thirion F, Bra-Maillet C, Guilly S, Simon C, Sothier M, et al

Funding: This work was supported by the Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP), grant 10/51906, Instituto Nacional de Cincia e Tecnologia de Processos Redox em Biomedicina (INCT Redoxoma), Ncleo de Apoio Pesquisa Redoxoma (NAP Redoxoma), Centro de Pesquisa, Inovao e Difuso de Processos Redox em Biomedicina (CEPID Redoxoma) grant 13/07937-8, and the John Simon Guggenheim Memorial Foundation

Viral inactivation was less effective at pH 6.5 (11 mM lactic acid), which resulted in 1 log inhibition of infection and required exposure to the acidic environment for 16 hrs

Acknowledgements Amer Zeidan is a Leukemia and Lymphoma Society Scholar in Clinical Research and is also supported by a NCIs Cancer Clinical Investigator Team Leadership Award (CCITLA)