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Cross-sectional studies reveal varying degrees of mast cell infiltration in kidney tissue from DKD patients across nearly all stages ( 4.2 Intrinsic immune molecules Monocyte chemotactic protein 1 (MCP-1), or CCL2, is a potent chemotactic factor for monocytes and the first identified human CC chemokine ( 2+ pathway ( Substantial evidence indicates that serum or urinary levels of inflammatory factors, including IL-1, IL-6, and TNF-, are significantly elevated in DKD (150, IL-10, an anti-inflammatory cytokine secreted by immune cells such as M2-type macrophages and CD4+ Treg cells, binds to IL-10R and IL-10R receptors on target cells

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doi: 10.3389/fcimb.2023.1280600 Received 20 August 2023 Accepted 06 October 2023 Published 25 October 2023 Volume 13 - 2023 Edited by Yash Gupta, Penn State Milton S

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I., Iwakura, Y