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Of relevance, HO-1 appears overexpressed both in brain and plasma of Parkinson patients and its upregulation by astrocytes promotes the -synuclein production, with consequent brain impairment and toxicity (115, 118)

In this regard precision-cut human liver slices (PCLiS), incubated in vitro, might represent a valuable ex vivo liver model for NA testing, due to preservation of both cellular composition, the three-dimensional architecture, and liver-specific functions of the donor liver

When NCOA4 expression is upregulated, it recognizes and binds to ferritin heavy chain 1 (FTH1) and mitochondrial ferritin (FTMT), interacting with autophagy-related factors and primary autophagosomes to form autophagosomes for lysosomal degradation, thereby releasing large amounts of Fe 2+ and forming the LIP

& Faraonio, R

One such emerging option is BPC-157 erectile dysfunction therapy