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Bioactive dietary polyphenols inhibit heme iron absorption in a dose-dependent manner in human intestinal Caco-2 cells
The antibody-drug conjugate according to claim 1, wherein D is a moiety of formula (IV)WhereinX is C or N, preferably N;Ring A is a heterocycloalkyl having 3 to 10 ring atoms, or a heteroaryl having 5 to 10 ring atoms, said heterocycloalkyl and heteroaryl being optionally substituted, preferably by one or more substituent selected from -OH, =O, C 1 -C 12 alkyl, C 1 -C 12 heteroalkyl, C 3 -C 6 cycloalkyl, heterocyclyl having 5 to 10 ring atoms, aryl having 6 to 10 ring atoms, heteroaryl having 5 to 10 ring atoms, -(C 1 -C 12 alkyl)-(C 3 -C 8 cycloalkyl), -(C 1 -C 12 alkyl)-(heterocycloalkyl having 3 to 10 ring atoms), -(C 1 -C 12 alkyl)-(heteroaryl having 5 to 10 ring atoms), -(C 1 -C 12 alkyl)-(aryl having 6 to 10 ring atoms), and -NR'R"
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5
For detection, SuperSignal West Femto Maximum Sensitivity Substrate (Thermo Scientific) was used as the chemiluminescence substrate and ImageQuant LAS 4000 mini (GE Healthcare) was used for imaging