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The mechanisms mentioned in this review related to tamoxifen resistance are summarized in Table 1

The reduction in oxygen results in the formation of superoxide, a product of single-electron reduction

This is the first clinical-grade safety signal in humans

The brain is constituted by a preponderance of microglia and astrocytes, these glial cells are essential in the Central Nervous System (CNS), with microglia functioning as innate immune cells involved in surveillance and defense, while astrocytes modulate neuronal communication, maintain the extracellular environment, and regulate inflammatory signaling (Garland et al., 2022) Both brain cells are able to produce pro- and anti-inflammatory cytokines (Schwarz and Bilbo, 2012)

It has even been found to act as an antioxidant to other antioxidants as it has the ability to maximise the activity of Vitamin C, Vitamin E and CoQ10