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To understand the proteome-wide selectivity of EN25, we next performed cysteine chemoproteomic profiling using isotopic tandem orthogonal proteolysis-enabled activity-based protein profiling (isoTOP-ABPP) [6,7]

Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and -synuclein oligomerization in a subacute MPTP mouse model of Parkinsons disease