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The reason a dentist will sometimes recommend removing one is to confirm the diagnosis on histopathology (microscopic examination of a tissue sample), particularly when the lesion is in a location where oral malignant melanoma is more likely (such as the hard palate or upper gum), or when the appearance has changed

(5) Wessells H, Levine N, Hadley ME, Dorr R, Hruby V

Growth hormonereleasing peptides raise IGF-1 and can secondarily affect sex steroids

Immunotherapy Keytruda (pembrolizumab), an immunotherapy, is approved for use in Stage IIB and IIC patients with melanoma who are 12 years and older, following complete resection of the melanoma

The oral manifestations, particularly the pigmented lesions on the lips and inside the mouth, serve as crucial diagnostic features and visual markers that can alert healthcare providers to the potential presence of PJS [80]