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doi:10.1007/s00253-001-0850-2

The peptide downregulates or inhibits key lipogenic enzymes including fatty acid synthase and acetyl-CoA carboxylase, which are responsible for converting excess dietary carbohydrates and other substrates into fatty acids for storage

Overall, these animal models have improved knowledge on motivation impairment that characterize NS, but they did not significantly contribute to clarify pathophysiological mechanisms underlying the other NS dimensions (i.e., alogia) and their interrelationships

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