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In the treatment of breast cancer, anti-estrogen tamoxifen, the drug most often used for the long-term treatment of early breast cancer, can induce apoptosis in many cells, and this effect may be mediated by ROS generation in the mitochondria of breast cancer cells [71]

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[DOI] [PubMed] [Google Scholar] 126.Xu X., Leo C., Jang Y., Chan E., Padilla D., Huang B.C., Lin T., Gururaja T., Hitoshi Y., Lorens J.B., et al