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Statistical analysis In the in vitro alkaline comet assay, significant differences between control and treated cells were evaluated using the unpaired Welchs t -test, one-tailed (PCLiS, PHH and HepG2 cells), as equal variance was not assumed, or paired t -test, one-tailed (PRH, due to variability of each rat), using TIBCOs Statistica (StatSoft GmbH, Germany)

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Clinical Considerations Disease-associated maternal and/or embryo/fetal risk During pregnancy, visceral adipose tissue increases due to normal metabolic and hormonal changes

Renues products are generally promising and typically dosed well, even despite a lack of clinical dosing guidance to rely on