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The renin-angiotensin-aldosterone system excites hypothalamic paraventricular nucleus neurons in heart failure

The peptide demonstrates ability to reduce production of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1), while promoting anti-inflammatory responses

Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat

And in patients with diabetes mellitus, there was a 41% reduction in clinical events, including a 43% reduction in deaths over 5 years