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The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion that does not respond to rest is a diagnostic criterion for ME/CFS

Therefore, histone H1 removal from somatic chromatin and consequent nucleosome destabilization at these sites by SSRP1 might facilitate ORC complex DNA binding leading to high replication origin assembly typical of embryonic cycles

(Click here to see works cited) Castellani, Daniele, et al

We treat the invisible patient by replenishing the cellular resources your body needs to repair itself before a breakdown occurs

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