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Furthermore, upregulation of mitochondrial ROS by TGF-1 induce senescence in lung epithelial cells (Yoon et al., 2005

It is likely that disease presentation and penetrance of underlying mutations are affected by a patient's comorbidities, including age, metabolic syndrome and hepatic steatosis, making certain patients more susceptible to fibrosis in FD

Here, they can typically last for 4-12 weeks

Energy expenditure and fat oxidation, or fat burning, were measured at the beginning of the study and during weeks 4, 8, and 12