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Pre-treatment With PLGA/Silibinin nanoparticles mitigates dacarbazine-induced hepatotoxicity

10.1038/nm.3159 210

doi: 10.1016/j.biopha.2023.114244 37 SakaguchiMOkagawaSOkuboYOtsukaYFukudaKIgataMet al

Conversely, A431 cells, with lower TGF1 secretion and basal HO-1 expression, show greater sensitivity to PDT when isolated but are more susceptible to develop resistance when exposed to exogenous TGF1, a response that is likely mediated by the induction of cell cycle arrest