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Characteristic magnetic resonance imaging findings in Machado-Joseph disease

Its 39-amino-acid chain with the attached fatty acid moiety creates a complex three-dimensional structure that depends on precise folding for biological activity

Ultrastructural analysis by transmission electron microscopy further suggested that in the TB-500 group, the newly formed collagen fibrils tended to be thicker, with diameters extending up to around 87 nm, compared to a maximum of 62 nm in control tissue