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Typically, molecules are found to be highly water soluble if the ratio of their total number of carbon atoms to the number of hydrophilic functional groups is less than about 31

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Dissociative anesthetics, including ketamine and nitrous oxide, impair glutamatergic transmission and mitochondrial function, thereby exacerbating excitotoxicity and neuronal apoptosis

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Problematic in practice when lighting is poor, the markings are tiny, and your hands are not perfectly steady

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