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Neurobiol Learn Mem 80:245256 Phillis JW (2005) Acetylcholine release from the central nervous system: a 50-year retrospective

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The effects of pregabalin and placebo were similar after the 3-week treatment, but mirogabalin at a dose of 15, 20, or 30 mg/day was significantly better than placebo in inducing a change in ADP score (0.94, 0.88, and 1.01, respectively) [37]

Studies (54, 55) have shown that the anti-RA effect of baicalin is related to the down-regulation of pro-inflammatory factors (TNF-, IL-1, and IL-6) and inflammatory markers (MMP-2, MMP-9, iNOS, and COX-2), the induction of monocyte apoptosis in synovial fluid of CIA mice, and the inhibition of JAK1/STAT3 and TLR2/MYD88/NF-B p65 signal transduction