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Interestingly, the mutation of ATP4Ap.R703C leads to gastric acid deficiency, and the disturbance of pH balance can directly affect the physiological function of the mitochondrial respiratory chain, causing ROS signaling to be activated and triggering caspase-3-mediated apoptosis in the host cells (Bentez et al., 2020)

A 2023 meta-analysis published in World Journal of Men's Health found that varicocele repair (varicocelectomy) improved sperm concentration by a mean of 9.7 million sperm/mL compared to observation alone