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Y.TangX

McLean, Heterozygous loss-of-function mutations in the AAGAB gene cause punctate palmoplantar keratoderma type 1 and impair receptor tyrosine kinase protein turnover

PAG phosphoinositol-glycan an antigen that is naturally a transmembrane protein e.g., a surface membrane protein on pathogenic viruses, bacteria, protozoa or tumor cells the extracellular domain can be engineered to be in fusion with the C- terminal sequence for signaling PIG-linkage

Studies focus on its ability to inhibit matrix metalloproteinases (MMPs), affect immune cell activity, and improve chemotherapy outcomes

Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes