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Anecdotal reports from Phase 2 participants suggest that nausea severity is higher when dosing occurs in the early morning on an empty stomach, possibly because fasting amplifies the compound's gastric-slowing effect

In addition to the practical challenges of preparing FACS-sorted cells for phosphoproteomics, the process of sorting itself can perturb the phosphoproteome

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In samples not sorted for the neuronal marker NeuN, the proportion of cell types varied across species: neurons constituted 50.2% of mouse cells, 41.2% of rat cells and 22.1% of macaque cells

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