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2.5 Combination therapy inhibits the growth of Th- MYCN mouse NB spheroids To assess the antitumor potential of the dual and triple drug combinations in a more physiological model than cell lines, we used a 3D spheroid model of a transgenic mouse that overexpresses MYCN under the control of the tyrosine hydroxylase (Th) promoter

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Apparent apoptosis was also induced in the central wing discs when smo was inhibited by the expression of smo-RNAi in the dpp-Gal4 domain (Fig