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Ouyang et al., 2024)

HiberCell, Inc

Downstream effects via active metabolites, gene-expression changes, and enkephalinase inhibition persist for hours to days, which is why dosing frequency is set by downstream windows rather than plasma kinetics

341,342 Although direct evidence for LPA-PPAR and LPA-RAGE activation is lacking, the established roles of these receptors in dendritic cell migration and Th2 responses suggest the possible augmentation of these responses by LPA