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Summary and future direction The inability of a medication to cross the BBB to achieve an effective therapeutic concentration in the brain has been the major cause of treatment failure for many brain diseases

Many of these purported super antioxidants have not been shown to be absorbed or maintained in the body in a way that would suggest that they would be meaningful antioxidants

Although taken orally for COPD, inhaled NAC has been approved for use in CF and has been shown to be effective as an adjunct therapy for IPF [46, 47]

The immune response to this damage, characterized by M1 macrophage polarization, neutrophilic inflammation, and Th17 activation, further exacerbates lipid peroxidation and ferroptosis, creating a vicious cycle that drives disease progression

GSH is shown as blue sticks