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To critically appraise mechanisms and levels of evidence ( in vitro, in vivo , clinical) for vitamin E and C, glutathione and its precursors, polyphenols (quercetin, resveratrol, curcumin), Crocus sativus carotenoids (crocin/safranal), and indirect modulators (e.g., omega-3, folinic acid), emphasizing study quality, translational relevance, and limitations

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Non-native disulfide bonds are often formed between incorrect cysteine residues, and thus the cell has dedicated a family of oxidoreductases that are thought to isomerize non-native bonds

Abstract Glutathione (GSH) is the classical example of a scavenging antioxidant

This PTM also occurs in mitochondria, regulating the OXPHOS and other mitochondrial functions [166]