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Another neurological symptom is depression, due to the deficiency leading to higher levels of oxidative stress, DNA damage, and cell death

Some individuals may experience an increase in symptoms like headaches or lethargy shortly after a B12 injection, this effect should be temporary and followed by symptom improvement

Disrupting the gut microbiota with broad-spectrum antibiotics or depleting B2 cells pharmacologically mitigated atherosclerosis, emphasizing the role of B2 cells beyond lipid metabolism (123)

Intrauterine inflammation and preterm delivery

In a family with PAIS associated with severe hypospadias, the length of the androgen receptor NH 2 -terminal poly-glutamine repeat has been reported to be shortened to only 12 glutamine residues (266)