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In contrast to its pro-inflammatory role in myeloid cells, NF-B has a protective role in intestinal epithelial cells, where it is required for maintaining epithelial integrity and intestinal immune homeostasis

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(I) The relevant mechanisms involved in each step of the intracellular GSH exhaustion process need to be further explored, and the biological effect of cancer cells after GSH depletion remains to be elucidated

For mild pigmentation, dermatologist-prescribed creams (with ingredients like kojic acid, niacinamide, arbutin, and retinoids) may be used to fade dark patches over time