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However, most EV engineering efforts have focused on EVs in the s-EV fraction, with the assumption that the EVs are largely derived from endosomes

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Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin