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Castriotta RJ, Eldadah BA, Foster WM, et al

Satoh, J., Kohara, N., Sekiguchi, K

This observation prompted the authors to consider whether the protective mechanism of A1AT involves not only the direct inhibition of NE activity but also an anti-inflammatory effect that prevents the release of TNF- alpha and subsequent infiltration of inflammatory cells

These hits were further analyzed using in vitro assays, eventually leading us to a primary lead, juglone

Understanding these epigenetic mechanisms can help identify how variations in ACL geometry might predispose individuals to injuries and guide the development of personalized prevention and treatment strategies