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Its triple GIP/GLP-1/glucagon agonist mechanism produced the most striking weight-loss numbers ever reported in a Phase 2 trial of an injectable peptide, and its broad TRIUMPH Phase 3 program is poised to expand understanding of how triple receptor modulation affects obesity, diabetes, liver disease, cardiovascular risk, sleep apnea, and musculoskeletal health

This is notable because PHGDH and PSAT1 are heavily lactoylated and LGSH inhibits PHGDH activity (35

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Interestingly and in contrast to CHAC1, CHAC2 is not localized to the mitochondria (Ward et al., 2024)