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identified a phenomenon termed white adipose tissue (WAT) browning, which takes place in the initial stages of cancer cachexia before skeletal muscle atrophy

Huang Q, Ou YS, Tao Y, Yin H, Tu PH

(2023) studied indole alkaloids from Alstonia scholaris and discovered that vellesamine and 19-epi-sholaricine showed protective effects against chronic glomerulonephritis by regulating proteins (cyclin-dependent kinase 2, GTPase hras (HRAS), vascular endothelial growth factor receptor 2 (KDR), and heat shock protein HSP 90-alpha (HSP90AA1) of the P13K-Akt pathway [76]